You may remember that not so long ago I wrote about what looked like a drug discovery success story for pain: anti-NGF therapy for osteoarthritis. Well, it looks like that success was short-lived. Somehow I missed this over the Christmas break, but, the FDA has ended trials on anti-NGF therapies for osteoarthritis due to development of avascular necrosis in some patients. Nothing positive can come of avascular necrosis and the pulling of several trials would suggest that this is a drug class effect (or at least suspected to be). Anyway you cut it, this is bad news.
- Short blog post on our work on AMPK activators for chronic pain: bodyinmind.org/ampk-metformin… 1 year ago
- NIH spends less than $0.50 per migraine patient on migraine research americanmigrainefoundation.org/support-the-fo… 1 year ago
- New article by yours truly on Pain Research Forum... What's up with PKMzeta? painresearchforum.org/news/23452-wha… 2 years ago
- or this one: informahealthcare.com/doi/abs/10.310… Thanks a ton 2 years ago
- anyone have access to this? onlinelibrary.wiley.com/doi/10.1016/j.… PDF to juniorprofblog at gmail dot com 2 years ago
- New Facebook page for University of Arizona Department of Pharmacology on.fb.me/OWPl1v 2 years ago
- What is hyperalgesia? What is allodynia?
- What is Central Sensitization?
- First step toward the holy grail of pain research? Molecular identity of a mechanically gated ion channel, Coste et al., 2010 Science
- A new mechanism of action for Selective Serotonin Reuptake Inhibitors (SSRIs)?: Pharm 551A, Baudry et al., 2010
- What causes chronic pain - or - how does pain become chronic?
- 373,733 fans